Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of ESRD.
Affected individuals inherit a defective copy of either PKD1 or PKD2, which encode
polycystin-1 (PC1) or polycystin-2 (PC2), respectively. PC1 and PC2 are secreted on urinary
exosome-like vesicles (ELVs)(100-nm diameter vesicles), in which PC1 is present in a
cleaved form and may be complexed with PC2. Here, label-free quantitative proteomic
studies of urine ELVs in an initial discovery cohort (13 individuals with PKD1 mutations and …